Bite-sized chunks of Great British Bioscience from BBSRC
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Slimming Seaweed bread
Obesity has reached epidemic levels globally, with at least 2.8 million people dying each year as a result of weight-related health problems (WHO).
BBSRC-funded Dr Matthew Wilcox is investigating the slimming powers of brown seaweed and his seaweed-bread combo may be a tasty way to tackle this widespread obesity.
The team from Newcastle University, led by Professor Jeff Pearson, found that alginate – a natural fibre found in sea kelp – stops the body from absorbing fat better than most anti-obesity treatments currently available over the counter, reducing the amount of fat absorbed by the body by around 75%.
After a gruelling judge’s shortlist and a nation-wide public vote, BBSRC’s Images with Impact category winners and runners-up have been selected.
These three images will now go head-to-head at the Great British Bioscience Festival, where the public will vote for the overall winner – with a total prize of £1000.
Find out more about the free Great British Bioscience Festival which will be held next week in Museum Gardens, Bethnal Green (November 14-16), at: http://www.bbsrc.ac.uk/gbbioscifest
Top image: Scanning electron microscopy of a polystyrene particle attached to a cleaning hair of an ant by Alexander Hackmann
Middle image: Rib and muscle by Mohammad Hajihosseini
When you think about the food that you eat, do you ever wonder what technology has helped to put it on your plate?
High-tech crop scanning equipment flying through the skies, near infra-red root analysis scanning crops underground, and world-class plant research facilities using novel techniques to feed the growing population.
BBSRC funds a range of science that’s delivering new solutions in food and farming, such as:
Sci-fi facilities at the IBERS National Plant Phenomics Centre - http://bit.ly/1uvxvtk
Warwick Crop Centre delivering research into crop breeding, plant pathology, entomology, agronomy, crop nutrition and environmental research - http://bit.ly/RosUcS
Top image: Rothamstead Research
Middle image: IBERS
Bottom image: Dr Oliver Smith from University of Warwick
You can find out more about some of the Great British Bioscience highlights that have occurred over the past 20 years by looking at BBSRC’s interactive timeline: www.bbsrc.ac.uk/timeline/.
The timeline shows where BBSRC’s investments have made a difference – from ground-breaking scientific discoveries, state-of-the-art facilities, shaping Government policies, to the impact that these have had for our society and the economy (see three examples above).
BBSRC-funded scientists are breaking down bacterial communities
These images by Dr Nicola Stanley-Wall, Dr Laura Hobley and Ms Rachel Gillespie from the University of Dundee show complex social communities of bacteria, known as biofilms.
Bacteria are single-celled organisms but they have the amazing capability to form these altruistic communities. Familiar examples of biofilms include dental plaque on your teeth and the slime that forms down your plug hole.
Biofilms made by a bacterium called Bacillus subtilis are waterproof because the cells make a ‘raincoat’ to protect themselves. You can see how effective this raincoat is by looking at the coloured water droplets that were placed on the biofilm pictured above.
When living in a biofilm community, bacteria are more resistant to antibiotics and are harder to remove from surfaces.
If we can understand what makes bacteria form a biofilm we can use this information to develop new ways to treat the chronic biofilm related infections that form on surgical implants, inside catheters, or in the lungs of people with Cystic Fibrosis.
Copyright: Thomas Endlein, University of Cambridge.
To enter this years Images with Impact competition, seeking the best images that showcase UK bioscience and its importance in everyday life, enter at: http://bbsrc2014.picturk.com/.
This striking image from BBSRC-funded Thomas Endlein shows an Asian Weaver ant, upside down on a smooth surface, and carrying a weight in its jaws.
Asian Weaver ants (Oecophylla smaragdina) can carry weights of more than 100 times their own body weight whilst upside down on a smooth surface. To do this, they have incredibly sticky pads on their feet.
Along with their extraordinary carrying capabilities weaver ants are also known for their territorial tendency. They readily defend against intruders making them a useful tool in controlling agricultural insect pests, avoiding the need for chemical insecticides.They have traditionally been used in this way in Chinese and Southeast Asian citrus orchards for at least 1,500 years.
To see more images from the last competition and to find out how to win the competition visit:
As part of the Great British Bioscience Festival, BBSRC is running Knit-a-Bug: The Great British Bioscience Knitting Competition. BBSRC invites knitters from across the UK to get creative with bioscience by knitting bacteria and viruses that can impact human and animal health.
Send in pictures of your knitted nasties for a chance to win a luxury knitter’s hamperand a subscription toSimply Knitting Magazine. Your bug will be judged by an expert team of scientists and knitters who will look for creativity and flair.
To enter, send in pictures of your knitted bugs to competition@bbsrc.ac.uk by 24 October 2014. Patterns for various bacteria and viruses are available to download from http://ow.ly/CbXLzor you can create your own.
Changing the properties of mucus to aid nutritional uptake
Lipase is an enzyme that the body uses to break down fats in food so they can be absorbed in the intestines. As a result of digestion by lipases, in the small intestine, lipid droplets from our food slowly release a complex array of self-assembled structures (coloured red) as shown in the top image. This range of particle types and sizes must diffuse through the mucus barrier if they are to be absorbed by the body.
In the bottom image, of a mouse small intestine, you can see the mucus layer (coloured green) in the environment that the lipid products must diffuse through in order to reach the gut wall where they can be absorbed. Cell nuclei are labelled blue and the mucus secreting goblet cells are seen secreting mucus into the space between the villi.
Dr Alan Mackie, from the Institute of Food Research, the only publicly funded UK research institute that focuses on the underlying science of food and health, studies what food structures and food component can be used to change the properties of the intestinal mucus. Understanding this process could allow us to control and modify nutritional uptake by manipulating the food structures and therefore their uptake through the mucus layer.
This research will be used to help design foods that can release their nutrients more slowly, which is helpful in the fight against the onset of type 2 diabetes and can also decrease appetite and may thus be used to combat obesity.
Professor Neil Hunter FRS and Dr Matt Johnson, together with a BBSRC-funded team from the University of Sheffield have made a breakthrough in our understanding of how plants turn sunlight into food, by mapping the organisation of a crucial protein complex known as cytochrome b6f. This has been done in the photosynthetic membrane of the plant cell chloroplast.
The team have developed a new imaging technique known as affinity mapping atomic force microscopy to pinpoint the location of cytochrome b6f relative to the chlorophyll-protein complex photosystem II. Locating a protein in a membrane is ordinarily a bit tricky, as they all often look quite similar. But Matt and his team have used this novel technique that involves attaching a molecule known as plastocyanin (blue) to the AFM tip (grey) and using this as ‘bait’ to ‘fish’ for the cytochrome b6f(fuschia), to which it binds with near 100% accuracy. This allows the topographic features of the membrane that are revealed in AFM image to be assigned to particular proteins based on whether they bind to the molecular bait.
Understanding the organisation of the molecular machinery of photosynthesis takes us a step closer to unravelling nature’s staggeringly successful blueprint for solar energy capture and conversion. Such fundamental research into photosynthesis is a first step towards harnessing the power of the sun to meet future energy needs.
This new technique could be used to locate other proteins in any biological membrane including in, plants, bacteria, and even humans, information that could be crucial to understanding how defective proteins can cause disease.
When you look at cool science images do you think about the technology behind the picture?
BBSRC funds a range of state-of-the-art imaging facilities that do more than just take a pretty picture.
One of these facilities is found at the Babraham Institute from where the images above, of HeLa cells at different stages of cell division, were taken.
The top image shows HeLa cells dividing into two. Cells (green) and chromosomes (blue). The Image was taken on a confocal microscope, a device which allows for live cell imaging with minimal specimen damage. Credit: Robert Cooper and Simon Walker
In the bottom image, HeLa cells can be seen at the end of the separation process, after cell division. Tubulin (green) nucleus (blue). The image was captured and reconstructed using a super resolution microscope. Image credit: Simon Walker
Advances in imaging technologies have revolutionized many fields of scientific research and their continued development is constantly changing the way we see science.
Zinc deficiency affects around 17% of the world’s population, mostly in developing countries. In Pakistan, the most recent national nutrition survey indicated that over 40% of women are zinc deficient. Stunted growth and development in children, increased susceptibility to infections, and complications during pregnancy and childbirth are just some of the consequences of zinc deficiency. Potentially leading to severe illness and death, this seemingly invisible deficiency has a negative economic impact on the family, the community, and the region more broadly.
So in May 2017 a group of researchers from the University of Central Lancashire started investigating whether a newly developed strain of biofortified wheat could increase dietary zinc intake in Pakistan by integrating the wheat into normal eating habits, and is being used is used to make chapattis – a staple food in the brick kiln communities of Peshawar.
Biofortified crops are developed using conventional plant breeding techniques, like cross-breeding standard varieties with their wild relatives over several generations. This means that biofortified crops are often more resilient to pests, diseases, higher temperatures and drought, as well as having higher micronutrient concentrations, such as zinc.
The trials were successfully completed in February this year, and the team are heading out to Pakistan this month to meet with research partners. The next steps are laboratory analysis, data entry and statistical analysis, and the team hope they will show improved zinc status associated with consuming bio-fortified zinc flour.
You know what’s really cool about writing for tumblr? I actively want to read the comments because we get good contributions and civil critique and interesting dialogue. Now that WADTT posts are getting shared off of tumblr I have to remember that not everyone is as cool as y’all and not to read the comments.