Togo and Seppala traveled 170 miles (274 km) from Nome in three days, and picked up the serum in Shaktoolik on January 31. The temperature was estimated at −30 °F (−34 °C), and the gale force winds causing a wind chill of −85 °F (−65 °C).

The return trip crossed the exposed open ice of the Norton Sound. The night and a ground blizzard prevented Seppala from being able to see the path but Togo navigated to the roadhouse at Isaac’s Point on the shore by 8 PM preventing certain death to his team. After traveling 84 miles (134 km) in one day, the team slept for six hours before continuing at 2 AM.

Before the night the temperature dropped to −40 °F (−40 °C), and the wind increased to 65 mi/h (105 km/h). The team ran across the ice, which was breaking up, while following the shoreline. They returned to shore to cross Little McKinley Mountain, climbing 5,000 feet (1,500 m). After descending to the next roadhouse in Golovin, Seppala passed the serum to Charlie Olsen, who in turn would pass it to Gunnar Kaasen and Balto.

Katy Steinmetz in Time Magazine wrote that “the dog that often gets credit for eventually saving the town is Balto, but he just happened to run the last, 55-mile leg in the race. The sled dog who did the lion’s share of the work was Togo. His journey, fraught with white-out storms, was the longest by 200 miles and included a traverse across perilous Norton Sound — where he saved his team and driver in a courageous swim through ice floes.”