Uhura's boop

i have not booped half of you as well as i would have liked, and i have booped half of you half as well as you deserve.

Tumblr rn

sagittarius, i am here to be how i please, and go where i truly feel free. showing others around me the how to be. i embody the light for all to see, how to live free.

. honeysiren🍒

Won’t lie, if I were having a rough time and the office himbos brought me mac and cheese I would be cured.

Small, clumsy kindnesses, earnestly given, are more healing than you would believe. More adults should be willing to show the tender caring that a little kid expresses when they say, “You looked sad, so I brought you a rock.”

Kind of crazy how much more interesting and beautiful real life caves are than most caves in video games. Never really seen em capture the diversity and composition it’s always just rock tubes connecting rock rooms with Sum glowing ass crystals

Join me in appreciating some Random ass caves I have seen

The far right justices in question are Clarence Thomas (75) and Samuel Alito (73). The likelihood that both will be able to remain on the bench until 2029, at the earliest, is small, especially with the growing ethics concerns around Thomas’ financial improprieties and his wife’s association with January 6 that may push his retirement even though he is currently (very) resistant. Thomas and Alito are the oldest members of the Court.

Re-electing Biden substantially increases the chances of the loaded 6-3 court shifting to 5-4, moving control away from the far right bloc, by 2029.

But it also has to be considered that Sonia Sotomayor, even though she is only 68, may not be able to remain on the bench through the next presidential term due to health concerns.

The first Trump presidency and Mitch McConnell’s scheming loaded the court with three right wing ideologues who barely qualify to teach law at Regent University, let alone have lifetime appointments to our highest court.

It is crucial to remember that the impact of a presidency on the courts outlasts any other presidential legacy and can change the entire course of American life for decades.

Is this a prank? What….

Edit: holy heck it’s real…

They might be able to help us…

The stage that they're at is animal testing but it sounds like it's been successful in mouse and primate models.

My understanding: The way autoimmune diseases usually seem to work* is the immune system is "flagging" the wrong thing as harmful/not needed and destroying it. The typical treatments for autoimmune diseases are just tamping the entire immune system down so it can't destroy anything, which leaves a person vulnerable to infection.

The newer method is basically "tricking" the body using a method that... the human body already came up with. Cells flagging the wrong thing apparently happens all the time, so there are multiple defenses against immune disease, and one of them is in the liver. So scientists figured out a way to tell the body "hey, you flagged this wrong" and sent it to the liver and the liver/body recognized this signal.

There is still a lot of work to be done and it sounds like this isn't foolproof (ie: what if the liver is whats broken? unsure, and what if the immune system flags things wrong again?) but this is literally so amazing. i was tearing up reading it, and i hope that everything goes well in clinical trials.

*theres like a lot medical science doesnt know about the immune system

Thank you for this explanation/synthesis of the article! It's important for us to understand that they're still in early development and testing of these methods, but also that they've seen it work in mice and primates (rather than just petri dishes of human cells). I hope this goes well.

Hi! I'm a microbiologist and I've done work in academia, pharma, and clinical trials.

So the most exciting thing about this article is the last paragraph tbh (working on getting the actual paper, it's not up on sci-hub yet).

The company mentioned, Anokion, has four registered clinical trials for both Celiac and MS patients. The trial for Celiac just submitted data from their phase 1 trial (meaning there's good data it is safe) and are recruiting for a Phase 1/2 trial (meaning they are now testing efficacy). After that, the big hurdle is phase 3, which looks at whether or not it is better than a current treatment. The projected completion date is spring 2025. They are also preparing for a Phase 2 trial but are not yet recruiting.

The phase 1 MS trial is currently active, estimated completion in summer 2024.

I checked the company website and it looks like they are in the process of submitting an investigational new drug (IND) application for Type 1 diabetes. This is the first step to starting clinical safety and efficacy trials.

Now clinical trials can get delayed for a variety of reasons, but this is a really good sign! It's way further along than I initially thought when seeing the news. If the treatment does well, we could see new drugs on the market for Celiacs as early at 2030ish and MS as early as 2035.

I literally just burst into tears and woke up my partners.

Holy shit. The idea of not having celiac disease anymore is so completely overwhelming.

Update: I have registered for the trial and if you also have celiac and want to register the link is here.

@xiaq

OH MY GOD???

i know absolutely nothing about autoimmune diseases but i do know a fair bit about research. please, if this is something that you think might be impactful for you, read up on clinical trials! the NIH has a super concise page here with a broad overview.

Note that phase I and (less often but not uncommonly) phase II drug trials are still working out the dosage levels, Phase I in particular will often involve testing the drug on completely healthy volunteers just to see if there is a maximum dosage/any side effects. The American Cancer society also has a decent breakdown of drug trials and how they are different.

Phase III generally involves the use of double blinding and placebos - meaning if you enroll in the Phase III trial, you may receive the drug, or you may receive a placebo so researchers can compare results.

☁️ this month i will worry less

🪷 this month i will prioritize my healing

🕯️ this month i will prioritize self care

📖 this month i will prioritize my feelings

🪩 this month i will make sure to have more fun

🩰 this month i will be more gentle and kind to myself

Thunderstorms are nature’s most fuckable events

the two bad fatigue moods:

If you want to write a dumb little story with a dumb little plot and ridiculously silly characters. No one's stopping you. Genuinely, no one should be allowed to stop you. Write that dumb story with your whole heart and don't hold back.

popping my back isnt enough i need to be picked up and slammed against the wall like a wet trout

You know how when you use a bendy straw you pull the bendy part up before you bend it? I want someone to do that to my spine.

unshrimp me back please

I'm the "voting is good" guy but I intend to direct basically all of my you-should-vote energy next year towards the reelection of the 18 progressives who've stuck their necks out to call for an Israeli-Palestinian ceasefire. They've dedicated themselves to a basic standard of human decency, and for it they will be punished with an immense tidal wave of financial and political resources seeking to get them kicked out of office, to say nothing of the threats against their lives. Biden's on his own.

None of them are from my state, unfortunately but predictably. But OP is right: if you live in one of these states, and in the right district, you're in a position to cast a vote that could actually matter.