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15-blade

@15-blade / 15-blade.tumblr.com

Surgery, art, medicine, baking, plants and cats.
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3liza

desquamation one of the top five medical words for one of the top five most unpleasant medical things that can happen to you. just a complete banger

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An original osteological preparation by Ryan Matthew Cohn, who is known for reviving the 19th-century tradition of developing medical education tools, created for a show at Museum of Arts and Design in 2014. It now resides in the collection of Tim K.

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I don't know if it was med school, residency, depression, or just the general and ever-increasing stresses of adulthood, but I feel like my potential for creativity and creation is dried up. I try to write, but I don't want to. I try to paint, but I don't want to. I went to all the trouble of hauling my old piano into the new house, yet I've touched it maybe 5 times. I was artistic once. I don't know where that part of me went. I am just so mentally exhausted all the time! All I have the cognitive bandwidth for is staring into space or sleeping.

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Now the fluoroquinolones go toe to toe! Both of these medications work by binding the topoisomerase IV/gyrase-DNA complex. Their most unique adverse effect is tendon rupture (avoid in kids and older adults!), and they shouldn't be used in myasthenia gravis patients as they can exacerbate the condition. Both can be used as post-exposure prophylaxis for anthrax. So which fluoroquinolone should move forward?

Ciprofloxacin: Of the fluoroquinolones, cipro has the best activity against both pseudomonas and gram negatives, notably the Enterobacteriaceae. It has a wide variety of uses, and among the most interesting (to me) are treatment of the plague and typhoid fever. On the more mundane side, it's mostly used for GI and GU infections. It can also be formulated as ophthalmic or otic drops for corneal ulcers/conjunctivitis and acute otitis externa, respectively. Beware though: it inhibits cytochrome P450, increasing the risk of drug interactions.

Levofloxacin: levo is considered a respiratory fluoroquinolone since it is mostly (but not exclusively) used for respiratory infections. While levo doesn't cover those fascinating bugs of plague and typhoid fever, it makes up for it by not inhibiting cytochrome P450. As with all fluoroquinolones, it should not be taken with dairy, as it can bind to the calcium and be rendered ineffective.

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