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A Level Biology Revision

@biologyalevel / biologyalevel.tumblr.com

This blog is mainly aimed at the WJEC spec. If you have any questions or need help feel free to drop us an ask
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biomedicool

Atherosclerosis

Accumulation of fatty material in the artery walls resulting in a narrowing or blocking

  • Affects mainly medium-large arteries
  • Only occurs in arteries with high pressure
  • Does not occur in veins unless exposed to systemic arterial pressures

Atheroma Formation 

  • disease of the tunica intima but can impact on the tunica media
  • accumulation of lipid rich material to for plaques

ONE

  • Endothelial damage occurs allowing entry to LDLs (low-density lipoproteins) into the tunica intima

TWO

  • Lipid taken up by macrophages in the intima
  • Accumulates to form a visible white bulge - fatty streak

THREE

  • Continued accumulation of lipids
  • cytokines from macrophages stimulate proliferation of intima cells with features of myofibroblasts
  • these secrete collagen - plaque starts to become fibrotic
  • lesions are more raised and yellower
  • as the lesion develops there is a pressure atrophy of the tunica media and the elastic lamina is disrupted

Four

  • Increased collagen secretion forms a dense, fibrous cap (fibrolipid cap) which is hard and white
  • this advanced plaque shows free lipid as well as the lipid in macrophages
  • collagen build up also weakens the arterial wall
  • endothelium is fragile and often ulcerates, allowing platelet aggregation and formation of a thrombus (clot) (thrombosis)
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Electron Transport Chain

  • Situated in the inner mitochondrial matrix
  • produces most eukaryotic ATP
  • a chain of proteins that move electrons from higher to lower energy levels
  • electrons are provided by FADH2 or NADH
  • terminal electron acceptor is oxygen
  • as electrons move to from high to lower energy levels, the energy is used to pump H+ against its concentration gradient out into the intermembrane space
  • this established concentration gradient drives the phosphorylation of ADP to ATP
  • oxidative phosphorylation

electrons flow from protein to protein spontaneously 

  • due to the relative electron affinities of the proteins
  • this tendency is known as redox potential

Click read more for detailed step by step

(only the first bit needed for a level)

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Mendel’s Laws

1. the Law of Dominance 2. the Law of Segregation 3. the Law of Independent Assortment

The Law of Dominance 

In a cross of parents that are pure for contrasting traits, only one form of the trait will appear in the next generation. Offspring that are hybrid for a trait will have only the dominant trait in the phenotype.

  • Mendel crossed many different combinations of pea plants
  • When pure tall plants crossed with pure short plants, all the new pea plants (referred to as the F1 generation) were tall.  
  • Similarly, crossing pure yellow seeded pea plants and pure green seeded pea plants produced an F1 generation of all yellow seeded pea plants. 
  • Instead of creating medium height plants or yellowy-green seeds that might have been expected, one trait came out as dominant
  • Ie there is a gene that codes for height. One allele (form of the gene) codes tall and another short. In this case, the tall is dominant
  • The dominant is represented with a capital letter (eg T for tall) while the recessive is lower case (t)

The cross Mendel performed was

Parents (P):  TT x tt

where T = the dominant allele for tall stems &  t = recessive allele for short stems

The punnet square looks like:

A plant that contains the dominant T will be tall, explaining why 100% of the plants he crossed came out tall.

The Law of Segregation

During the formation of gametes (eggs or sperm), the two alleles responsible for a trait separate from each other.  Alleles for a trait are then “recombined” at fertilization, producing the genotype for the traits of the offspring.

Now, Mendel decides to cross the offspring from the above experiment - all Tt

  • Two of the “F1” generation (tall) are crossed
  •  Would assume to get all tall again as tall is dominant
  • HOWEVER some come out short
  • “F2″ generation is about ¾ tall & ¼ short

Therefore:

  • Parent plants for this cross each have one tall factor that dominates the short factor & causes them to grow tall.
  • To get short plants from these parents, the tall & short factors must separate (allowing the possibility of 2 short factors coming together without a dominant tall) otherwise a plant with just short factors couldn’t be produced
  • The factors must SEGREGATE themselves somewhere between the production of sex cells & fertilization

Two hybrid parents, Tt x Tt.

The punnet square would look like this:

This splitting happens during meiosis.

The Law of Independent Assortment

Alleles for different traits are distributed to sex cells (& offspring) independently of one another.

  • Previously Mendel addressed one trait at a time.  
  • He noticed that different traits had no effect on each other, eg being tall didn’t automatically mean the plants had to have green pods
  • The different traits seem to be inherited INDEPENDENTLY.

The genotypes of our parent pea plants will be:

RrGg x RrGg where "R” = dominant allele for round seeds “r” = recessive allele for wrinkled seeds “G” = dominant allele for green pods “g” = recessive allele for yellow pods

The results from a dihybrid cross are always the same:

  • 9/16 boxes (offspring) show dominant phenotype for both traits (round & green), 
  • 3/16 show dominant phenotype for first trait & recessive for second (round & yellow) 
  • 3/16 show recessive phenotype for first trait & dominant form for second (wrinkled & green)
  • 1/16 show recessive form of both traits (wrinkled & yellow).

Summary:

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did u write notes on meisos? please share and can u please tell me the difference between semi lunar valve and atriventricular valves?

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The semilunar valves are the aortic and pulmonary valves (located at the bases of the aorta and the pulmonary trunk)

  • These arteries receive blood from the ventricles 
  • semilunar valves allow blood into the arteries
  • prevent backflow from the arteries into the ventricles. 
  • closure of the semilunar valves causes the second heart sound (’dub’ of the ‘lub-dub’)

The atrioventricular valves are the mitral (bicuspid) and tricuspid valves (located between the atria and the ventricles)

  • Prevent backflow from the ventricles into the atria during systole (ventricle contraction)
  • Anchored to the walls of the ventricles by chordae tendineae (semilunar don’t have these!!), which prevent the valves from inverting (going inside out)
  • chordae tendineae are attached to papillary muscles, together, they're known as the subvalvular apparatus
  • closure of the AV valves causes the first heart sound (’lub’ of the ‘lub-dub’)

So, the semilunar valves are the ones between arteries and heart, and the atrioventricular valves are the ones inside (conveniently, between the atria and the ventricles) hope this helped!! Did you want any more details on the valves?

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biomedicool

Rough Endoplasmic Reticulum

  • Rough ER (RER) is involved in some protein production, protein folding, quality control and despatch
  • Called ‘rough’ because studded with ribosomes
  • Smooth ER (SER) is associated with the production and metabolism of fats and steroid hormones
  • Smooth because no ribosomes and is associated with smooth, slippery fats.

STRUCTURE

  • Continuous membrane of flattened sacs (cisternae) and network tubules, touching nuclear membrane. 
  • Membrane bound ribosomes firmly attached to the outer cytosolic side of the RER
  • However these are constantly being bound and released - will only bind when specific protein-nucleic acid complex forms in cytosol 
  • FUNCTION
  • Proteins are made by the ribosomes on the surface of the RER - translation
  • Then (some) are threaded inside RER to be modified and transported
  • RER working with membrane bound ribosomes takes polypeptides and amino acids from the cytosol and continues protein assembly including, at an early stage, recognising a ‘destination label’ attached to each of them. 
  • Proteins are produced for the plasma membrane, Golgi apparatus, secretory vesicles, lysosomes, endosomes and the ER. 
  • Some  proteins into the lumen (inside) of the RER; others are processed in RER membrane itself
  • Lumen: some proteins have sugar groups added to form glycoproteins; some have metal groups added
  • EG: in RER four polypeptide chains are brought together to form haemoglobin.

Protein folding unit lumen of the rough ER: proteins folded to produce biochemical architecture which will provide ‘lock and key’ and other recognition and linking sites.

Protein quality control section

  • Lumen: incorrectly formed or incorrectly folded proteins rejected
  • Rejects stored in the lumen or sent for recycling for eventual breakdown to amino acids. 
  • A form of cystic fibrosis = missing single amino acid, phenylanaline, in a particular position in the protein construction. Quality control section spots the error and rejects, however individual would have been better off with poor product than none at all

From Rough ER to Golgi In most cases proteins are transferred to the Golgi apparatus for ‘finishing’. They are conveyed in vesicles or possibly directly between the ER and Golgi surfaces. After ‘finishing’ they are delivered to specific locations.

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Also what's the name of the study(ish) blog that you've made, if you don't mind my asking

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your other question: I was wondering, what professions are there regarding biomedical science?

I’m going down the medical research path (so i’ll be specialising) but this is a question i’ve answered on the above blog - people in hospitals who analyse all the samples taken by the doctors are biomedical scientists. So, the doctor takes a blood sample, sends it off to the biomeds who then tell the doctor what’s wrong with the patient. Here’s a site with more info :)

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STILL HERE

Hey guys, 

Just wanted to let you know I'm still here if anyone has any questions to ask. Ask away. I will explain it with pictures and videos. Im on my gap year, and need to keep up with biology!!

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Hi! Original owner of this blog here

I’m now at uni studying biomedicine, and i’ve made a study(ish) blog much like this one for my notes and other interesting science stuff. Give it a follow if you think it’ll interest you! I can help with all things biomedical science, and am also happy to give advice relating to studying, university and A levels :)

biomedicool​

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Revision BY4

If anyone has any last minute confusions with BY4 let me know. I will help you and everything :-)

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Oh the contradictions of AS WJEC Biology ahaha

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Ahhhh Biological Molecules only just fits on two sides of a massive A2 poster !!! #revision #alevel #biology #biologicalmolecules

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Annotation of a myelinated motor neurone. Direction of impulse going from the dendrites to axon terminals

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I went on tumblr to procrastinate and saw the picture of the nervous pathways haha biology won't leave me alone!!! Btw great blog keep it up :)

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Hahaha nothing better than accidently learning whole procrastinating ;) thank you :) Good luck on your exams and if you want any bio diagrams explanations let me know :)) Madi

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