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Martial arts, science, and whatever

@shotokanandscience-blog / shotokanandscience-blog.tumblr.com

I'm a molecular biologist that also happens to be studying Shotokan Karate with my wife. When I started this blog I was an orange belt (8th kyu) I stopped at brown belt (1st kyu). After many changes in my life I am in the process of getting back into it.
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cikero

I’m so mad that a t4 bacteriophage actually looks like that and that it’s appearance isn’t made up

this is how they look in all the models

this is how they actually look

like they really fucking look like that. in real life

viruses are literally such bullshit they have the nerve to look like this and they aren’t even ALIVE

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nuggettiana

I REFUSE TO ACCEPT THE SHITTY AND ARBITRARY DEFINITION OF LIFE THAT MAKES VIRUSES NOT ALIVE. FUCK YOU THEY ARE ALIVE

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petzah394

Things are heating up in the virus fandom

thats called a fever

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Anonymous asked:

As a trans guy, going through the transmasc and transman tags and blocking every single account that misuses the transmasc tags has improved my experience on tumblr so much.

It's a special kind of fucked up that I had to start blocking accounts to see trans masculine posts at the top of the transmasc tag. Before I started blocking, every time I looked at the top posts in the trans masc tag, it was a bunch of women in bikinis who put EVERY trans tag on their photos to boost their search visibility.

Fuck anyone that does that.

Trans men are already ignored and erased most of the time. Let us have one fucking space to ourselves ffs.

Thanks for letting me vent.

not to override the point of your post (totally true and valid complaint) but the amount of nsfw content i see under the trans tags is horrendous

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Taking it further I’m sick of seeing forced femme, sissy stuff, and sissy kinks tagged as trans. If you are into that thing that’s great. However, it doesn’t belong in trans femme or trans masc tags etc. let us have our clear spaces to see the content we are looking for not boost your post visibility to a bunch of people that don’t want anything to do with it.

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teruterusky

btw the thing she couldn’t ignore was someone calling her out for saying anti-depressants/hormone therapy are only perscribed by lazy doctors

Update:

J.K. Rowling is apparently now filing a defamation lawsuit against someone who made fun of her for saying this, which means its time to spread this like wildfire!

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The free market does not have an invisible hand. Social necessities are made scarce, then monetized by private equity.

The free market is self-interest. End of story.

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Attention Transphobes

I am well beyond the point where you can tell me I look masculine and I'll believe it. If you do this, I will laugh at you. Then everyone else in the notes will laugh at you because you look fucking ridiculous.

If you're gonna insult me, at least try something that isn't so obviously disproven by looking at your damn phone/computer screen.

↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑

Manly Masculine Burly Tough Guy, Apparently

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Anonymous asked:

“As a biologist, the terms biological woman and man don’t make any sense to me” okay then you’re an idiot and a terrible biologist. I swear to god, morons like you only become biologists just so you can hold it over others, when in reality, if biology deniers like you can become biologists, then being one really doesn’t mean much anyway. But this probably just gave an autogynophile like you a boner to read, anyway.

Oh fun! Haven't gotten one of these in a while. Disregarding the fact that you somehow think the qualification for being a biologist entirely hinges on defining womanhood, I do need to ask some clarification. I know I'm feeding the trolls here, but here we go: does your definition of "biological woman" mean:

Sociological woman? Eh, context dependent, I'm not fully out of the closet, but oftentimes, I am and present femme. So let's call that one 50/50.

Psychological woman? Because I am one.

Neurological woman? Because I am one [1].

Physical woman? My soft tissue redistribution is handling that well.

Hormonal woman? My blood tests are within cis female ranges.

Transcriptional woman? As a signalling molecule, the downstream effects of estrogen have broad transcriptional effects, completely changing the profile of gene expression and functional genomics of my cells. [2]

Genetic woman? I mean, see my above point- as far as my genes that are actually active, I have all of the same transcripts being produced, controlling which genes are expressed.

Karyotypic woman? I actually have a few signs pre-HRT that might point to a non-XY chromosome pair, but I haven't had a karyotype. We'll put that down as unknown. And hell, even if its XY, there's plenty of cis women who are karyotypically XY, with suppressed sry or complete androgen insensitivity. Interestingly enough, a completely androgen insesitive woman can go her whole life without knowing- and functionally, is very similar to a trans woman, actually. Fancy that. [3]

Reproductive woman? I can't produce an egg cell, but neither can significant fractions of cis women. Also, this is all gonna change soon, which is fun. [4]

There's also a lot of understudied aspects to the biology of HRT and even pre-HRT that are emerging, largely demonstrating widespread cellular and genetic remodeling of trans individuals undergoing hormone therapy. The field is a bit behind due to constant political pressure to revoke funding, but a lot of the results are extremely exciting in both testosterone and estrogen hormone therapies. I'm sure that, as a self professed biology As someone who presumably has a lot of expertise in biology, I'm assuming that you're aware of all of this cutting edge research, and are keeping up with modern papers, including but not limited to these cool findings:

  1. Trans men on HRT exhibit significant genetic and transcriptional changes that make them biochemically male. [5][6]. It's a good hypothesis that the same happens with estrogen treatment, but those studies don't exist yet- I'm sure you're reserving judgment until more publications exist, of course.
  2. Trans men on HRT develop male cell types and tissues. [7]
  3. Trans women experience muscular and blood cell changes that align with cis women moreso than cis men [8]
  4. And many, many more! This is an exciting, underserved, and groundbreaking field of research, and I'm sure you're keeping up with the latest in scientific journals about it.

I'm sure, of course, that you understand that it becomes impossible to draw a distinct line anywhere in here, and that words like "woman" are shorthand for the myriad of traits that invisibly synthesize in our mind and in society to represent a concept? I'm sure you understand that science is fundamentally descriptive, not prescriptive? I'm sure that you understand that these findings, while really cool and interesting, actually don't mean jack shit about what the word "woman" means or not?

As someone who is the ultimate decider in what a biologist is, I'm sure you know that bioessentiallism is a childish mindset that completely ignores and disregards the constantly changing, dynamic nature of biological systems, something that extends well beyond biological sex and its relation to gender.

I'm sure that also, that you understand that beyond just this, that the role of science in society is to advise how to achieve our moral principles, not create moral principles in themselves. And I'm sure that understanding means you know that trans affirming healthcare and supportive societal treatment leads to reduced mortality and increased happiness for everyone, right?

So great to talk to someone who is surely a scientist on this. You are a biologist, if you're talking like this, I assume? I assume you're not going to spit complete misreadings of scientific language from the background sections of these papers that only reveal you've never read a scientific paper in your life if you're thinking this way? I assume you have experience interpreting data like this?

Also, imagining my genitalia while writing this? Ew. Please stop projecting your fetishes into my inbox.

Works cited:

  1. Kurth F, Gaser C, Sánchez FJ, Luders E. Brain Sex in Transgender Women Is Shifted towards Gender Identity. J Clin Med. 2022 Mar 13;11(6):1582. doi: 10.3390/jcm11061582. PMID: 35329908; PMCID: PMC8955456.
  2. Fuentes N, Silveyra P. Estrogen receptor signaling mechanisms. Adv Protein Chem Struct Biol. 2019;116:135-170. doi: 10.1016/bs.apcsb.2019.01.001. Epub 2019 Feb 4. PMID: 31036290; PMCID: PMC6533072.
  3. Gottlieb B, Trifiro MA. Androgen Insensitivity Syndrome. 1999 Mar 24 [Updated 2017 May 11]. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1429/
  4. Murakami, K., Hamazaki, N., Hamada, N. et al. Generation of functional oocytes from male mice in vitro. Nature 615, 900–906 (2023). https://doi.org/10.1038/s41586-023-05834-x
  5. Pallotti F, Senofonte G, Konstantinidou F, Di Chiano S, Faja F, Rizzo F, Cargnelutti F, Krausz C, Paoli D, Lenzi A, Stuppia L, Gatta V, Lombardo F. Epigenetic Effects of Gender-Affirming Hormone Treatment: A Pilot Study of the ESR2 Promoter's Methylation in AFAB People. Biomedicines. 2022 Feb 16;10(2):459. doi: 10.3390/biomedicines10020459. PMID: 35203670; PMCID: PMC8962414.
  6. Florian Raths, Mehran Karimzadeh, Nathan Ing, Andrew Martinez, Yoona Yang, Ying Qu, Tian-Yu Lee, Brianna Mulligan, Suzanne Devkota, Wayne T. Tilley, Theresa E. Hickey, Bo Wang, Armando E. Giuliano, Shikha Bose, Hani Goodarzi, Edward C. Ray, Xiaojiang Cui, Simon R.V. Knott, The molecular consequences of androgen activity in the human breast, Cell Genomics, Volume 3, Issue 3, 2023, 100272, ISSN 2666-979X, https://doi.org/10.1016/j.xgen.2023.100272. (https://www.sciencedirect.com/science/article/pii/S2666979X23000320)
  7. Xu R, Diamond DA, Borer JG, Estrada C, Yu R, Anderson WJ, Vargas SO. Prostatic metaplasia of the vagina in transmasculine individuals. World J Urol. 2022 Mar;40(3):849-855. doi: 10.1007/s00345-021-03907-y. Epub 2022 Jan 16. PMID: 35034167.
  8. Harper J, O'Donnell E, Sorouri Khorashad B, McDermott H, Witcomb GL. How does hormone transition in transgender women change body composition, muscle strength and haemoglobin? Systematic review with a focus on the implications for sport participation. Br J Sports Med. 2021 Aug;55(15):865-872. doi: 10.1136/bjsports-2020-103106. Epub 2021 Mar 1. PMID: 33648944; PMCID: PMC8311086.
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rick riordan off the shits

rick riordan made his bones with pretty vanilla YA fantasy and then when he was too successful to stop hit em with the Muslim valkyries and the genderfluid homeless teenagers

Rick Riordan’s “vanilla YA fantasy” series was written for his son with ADHD and dyslexia because there weren’t any books about kids with learning disorders. He “made his bones” on representation, you just didn’t notice because disabled people don’t count.

Slammed that

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rowark
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goomymegpoid

I wish this feeling upon everyone who wants to wear a dress, its really the best

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ghostlynblm

this makes me so happy as a fat hairy guy who likes skirts and dresses i never get to see guys like me in dresses it’s always skinny twinks this makes me so happy 🥺🥺

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elierlick

Jordana LeSesne (1.8.7) is a Black trans woman. She is widely regarded as the top drum and bass producer in the world. Without her, we wouldn’t have electronic music as we know it today. 

She came out in 1998 and went on to get a contract with the Syfy Channel, be profiled in Rolling Stone, and have several albums chart in the Top 25.

She also mixed the original music for the FREE Cece documentary!

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gaydesigner

Her first few albums on Spotify

Her recent work on SoundCloud and mixcloud

Her new stuff is good! Check it out ^

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neil-gaiman

Mr. Gaiman on my paper about the literary value of comics I cited you for your sandman comic as quote that kick ass guy Neil Gaiman and I forgot to take it out before I turned it. my teacher told me unless I can get the approval of you I will get detention. Idk if she was serious but incase she was can I have your approval?

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Just in case she was serious, it's nice to be a kick ass guy.

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