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I’m so mad because this worked

help me roger

Reblogging myself because

Originally posted by gifs-for-the-masses

Reblogging myself because… what was that? Five minutes?

O_O

………my friend has made me curious

help me roger

Update: after I reblogged this someone messaged me offering me tickets to the sold out Hausu screening with a Q&A and autograph session with the director

These never work for me, but here’s to trying.

Eh Roger is cute I might as well

That fish is so happy it makes me happy.

I have no luck right now. Halp.

Why does this have so many notes

because its not one of your posts.

Roger is precious to me.

Help me Roger

I mean…. my page is dead anyways. No one comments or asks questions via the ask thing so I guess I could.

I believe in penny. She’s an unstoppable force.

there's indoor cats, there's outdoor cats, and then there's penny

The threead continues:

The book linked is free to read and download. See the link above.

if you’re a transfem you should read this, and if you’re not you should reblog it for your transfem friends & followers, the advice in here is extremely good and the grips breaks are not hard to practice!!

"In a historic “first-of-its-kind” agreement the government of British Colombia has acknowledged the aboriginal ownership of 200 islands off the west coast of Canada.

The owners are the Haida nation, and rather than the Canadian government giving something to a First Nation, the agreement admits that the “Xhaaidlagha Gwaayaai” or the “islands at the end of world,” always belonged to them, a subtle yet powerful difference in the wording of First Nations negotiating.

BC Premier David Eby called the treaty “long overdue” and once signed, will clear the way for half a million hectares (1.3 million acres) of land to be managed by the Haida.

Postal service, shipping lanes, school and community services, private property rights, and local government jurisdiction, will all be unaffected by the agreement, which will essentially outline that the Haida decide what to do with the 200 or so islands and islets.

“We could be facing each other in a courtroom, we could have been fighting each other for years and years, but we chose a different path,” said Minister of Indigenous Relations of BC, Murray Rankin at the signing ceremony, who added that it took creativity and courage to “create a better world for our children.”

Indeed, making the agreement outside the courts of the formal treaty process reflects a vastly different way of negotiating than has been the norm for Canada.

“This agreement won’t only raise all boats here on Haida Gwaii – increase opportunity and prosperity for the Haida people and for the whole community and for the whole province – but it will also be an example and another way for nations – not just in British Columbia, but right across Canada – to have their title recognized,” said Eby.

In other words, by deciding this outside court, Eby and the province of BC hope to set a new standard for how such land title agreements are struck."

-via Good News Network, April 18, 2024

Press release by the Haida Nation about the vote

Two really great things about this:

1- they didn't have to go to court. Cases like this usually take years or decades and are incredibly expensive for First Nations, even if they win.

2- to quote the press release: "In the agreement, British Columbia recognizes and affirms that the Haida Nation has Aboriginal title to the lands of Haida Gwaii. This recognition does not create title – Haida Title is inherent." That's a big deal!! The difference between Canada granting title versus recognising Aboriginal title is incredibly important in matters of sovereignty. Haida sovereignty and Aboriginal title is inherent; it does not need to be "given" by the Canadian government.

All true!! Thank you so much for the excellent additions

This advertisement is for Can’t Spell Treason Without Tea by Rebecca Thorne, a cozy fantasy steeped in sapphic romance about one of the Queen’s private guards and a powerful mage who want to open a bookshop and live happily ever after…if only the world would let them.

WHAT IT’S ABOUT

All Reyna and Kianthe want is to open a bookshop that serves tea. Worn wooden floors, plants on every table, firelight drifting between the rafters…all complemented by love and good company. Thing is, Reyna works as one of the Queen’s private guards, and Kianthe is the most powerful mage in existence. Leaving their lives isn’t so easy.

But after an assassin takes Reyna hostage, she decides she’s thoroughly done risking her life for a self-centered queen. What follows is a cozy tale of mishaps, mysteries, and a murderous queen throwing the realm’s biggest temper tantrum.

Is this a prank? What….

Edit: holy heck it’s real…

They might be able to help us…

The stage that they're at is animal testing but it sounds like it's been successful in mouse and primate models.

My understanding: The way autoimmune diseases usually seem to work* is the immune system is "flagging" the wrong thing as harmful/not needed and destroying it. The typical treatments for autoimmune diseases are just tamping the entire immune system down so it can't destroy anything, which leaves a person vulnerable to infection.

The newer method is basically "tricking" the body using a method that... the human body already came up with. Cells flagging the wrong thing apparently happens all the time, so there are multiple defenses against immune disease, and one of them is in the liver. So scientists figured out a way to tell the body "hey, you flagged this wrong" and sent it to the liver and the liver/body recognized this signal.

There is still a lot of work to be done and it sounds like this isn't foolproof (ie: what if the liver is whats broken? unsure, and what if the immune system flags things wrong again?) but this is literally so amazing. i was tearing up reading it, and i hope that everything goes well in clinical trials.

*theres like a lot medical science doesnt know about the immune system

Thank you for this explanation/synthesis of the article! It's important for us to understand that they're still in early development and testing of these methods, but also that they've seen it work in mice and primates (rather than just petri dishes of human cells). I hope this goes well.

Hi! I'm a microbiologist and I've done work in academia, pharma, and clinical trials.

So the most exciting thing about this article is the last paragraph tbh (working on getting the actual paper, it's not up on sci-hub yet).

The company mentioned, Anokion, has four registered clinical trials for both Celiac and MS patients. The trial for Celiac just submitted data from their phase 1 trial (meaning there's good data it is safe) and are recruiting for a Phase 1/2 trial (meaning they are now testing efficacy). After that, the big hurdle is phase 3, which looks at whether or not it is better than a current treatment. The projected completion date is spring 2025. They are also preparing for a Phase 2 trial but are not yet recruiting.

The phase 1 MS trial is currently active, estimated completion in summer 2024.

I checked the company website and it looks like they are in the process of submitting an investigational new drug (IND) application for Type 1 diabetes. This is the first step to starting clinical safety and efficacy trials.

Now clinical trials can get delayed for a variety of reasons, but this is a really good sign! It's way further along than I initially thought when seeing the news. If the treatment does well, we could see new drugs on the market for Celiacs as early at 2030ish and MS as early as 2035.

I literally just burst into tears and woke up my partners.

Holy shit. The idea of not having celiac disease anymore is so completely overwhelming.

Update: I have registered for the trial and if you also have celiac and want to register the link is here.

clocking in for another day at the i dont wanna factory

[ID: Six unrelated sketches of Hardison, Parker and Eliot from Leverage. Top left is Eliot standing in the foreground with a boody nose and a cut on his cheek, glaring ahead, while Parker and Hardison are behind him smiling. Top right is Parker standing slightly behind Eliot, and both of them smiling at each other. Middle left is Eliot leaning forward to talk to Hardison, and Hardison turning to look at him over his shoulder. Middle right is Eliot standing with his arms folded, smiling slightly while he watches Hardison typing at a laptop, looking serious. Bottom left is Hardison leaning in towards Eliot so his face is right by his hair and smiling, making Eliot laugh. Bottom right is the three of them standing looking seriously, with Hardison seated and the other two standing, as if looking over his shoulder at a laptop. End ID]

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Trying to get out of chaos-induced art slump by random sketching, so here are some random sketches.

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Prehistoric asshole cat  (X)

occasional posts from users

reblog if you make occasional posts

Sometimes I still hear my voice