@kyosplosion / kyosplosion.tumblr.com
Both were filled at the same time with the same water, only one had oysters.
Wtf. No, be who you are. This doesn’t define you.
I offer some context
that context was DESPERATELY needed thank you
when i started my last director job at a university, they told me one of my duties would be to write all the chancellor’s letters. me: “cool. but why though?” them: “English isn’t the chancellor’s first language.” me: “I’m aware of that.” them: “the chancellor likes the suggestions that autocorrect gives him if he misspells something.” me: “Ah.” them: hands me a copy of a letter the chancellor sent to a donor who had just given a million-dollar gift to the university, which includes the following: ‘The profundity of your gift fills us with the greatest horror. In recognition we have prepared a special plague to compromise you and your family’.
Which is why to this day when I’m struggling to communicate in a different language, i remember the chancellor, who was Doing His Best, and i try to give myself a break.
my advice to you is to never waste your time trying to fit into a club or hobby or any community who makes you beg for acceptance and approval just to participate when you could do the alternative—get involved in a niche and endangered hobby run primarily by old people.
i wanted to learn how to hunt ruffed grouse and train bird dogs so i sent an email to my local chapter of the ruffed grouse society explaining that getting into wildlife groups is intimidating to me because I’m trans
and all they saw was that someone under 60 wanted to learn to hunt grouse & several months into my mentorship I was told that like 7 old guys argued over me until they had to pick a number between 1 and 100 to decide who got to personally mentor me.
imagine vying for the acceptance of some gatekeeping weirdos when your mere interest could be inciting verbal combat among retirees
my mentor was so sweet & funny too. he suggested we meet over lunch first so he could tell me about what to expect before we got started & I emailed back “I’m ready to get started right away!”
and he said “I was actually suggesting lunch first for your comfort on the assumption you wouldn’t want to get together with a man you’ve never met, in the woods with a gun.”
Like, I trusted him because of the referrals I got from one of my professors but like, right you are sir fair enough. Lunch it is.
this is the closest you can get to experiencing a jumpscare on social media
Guy eating pussy but he's got one of those Bluetooth earpieces on and on the other end is a lesbian instructing him how to do it.
Remember when you were a kid and believed people got high up and powerful positions in law and politics because they were genuinely the smartest and most competent in their field?
Think I just found @amtrak-official's favorite wrestler
I have finally found a reason to go to a wrestling match
They’re great!
I saw someone post about how they hope the writers got rid of Sokkas “stupid humor” for the live action show and like damn I don’t think someone had fundamentally misunderstood a character more.
Sokkas humor is a huge part of his character and shows a major aspect of his growth. At the beginning of the show Sokka is NOT the funny guy. In fact, he’s the most serious dude in his village. In the pilot, Aang and Katara are off playing with penguins while Sokka is literally putting on war paint and preparing to defend the rest of the village from a Fire Nation war ship. He has been the only man in his village for like four years. And he’s only fourteen. Sokka doesn’t make jokes at first, and when he does they’re usually sexist because his whole thing is about how much of a man he is. Sokka developing humor signifies his growth is a thousand ways. How he learns to respect others. How he starts to make friends. And more importantly, how he turns from a man back into a boy.
so I started a new anxiety medication this past week and so far it’s been going very well except that I have extremely vivid dreams and apparently sleep texting. I seem to have sent this at 3am and i have no memory of it
but i am Right
okay this reminded me. i’m disabled and i’ve gone to the hospital a lot and one time in college during finals season i had to write my professor an email excusing my absence but the dilauded kicked in and well
i was not born in 1998
okay but if i get that note from a student, i am in fact excusing them
my prediction for the fanon interpretations of the agents post-side order
this is so fucking funny
happy 10th birthday to beautiful cinnamon roll too good for this world, too pure
Is this a prank? What….
Edit: holy heck it’s real…
They might be able to help us…
The stage that they're at is animal testing but it sounds like it's been successful in mouse and primate models.
My understanding: The way autoimmune diseases usually seem to work* is the immune system is "flagging" the wrong thing as harmful/not needed and destroying it. The typical treatments for autoimmune diseases are just tamping the entire immune system down so it can't destroy anything, which leaves a person vulnerable to infection.
The newer method is basically "tricking" the body using a method that... the human body already came up with. Cells flagging the wrong thing apparently happens all the time, so there are multiple defenses against immune disease, and one of them is in the liver. So scientists figured out a way to tell the body "hey, you flagged this wrong" and sent it to the liver and the liver/body recognized this signal.
There is still a lot of work to be done and it sounds like this isn't foolproof (ie: what if the liver is whats broken? unsure, and what if the immune system flags things wrong again?) but this is literally so amazing. i was tearing up reading it, and i hope that everything goes well in clinical trials.
*theres like a lot medical science doesnt know about the immune system
Thank you for this explanation/synthesis of the article! It's important for us to understand that they're still in early development and testing of these methods, but also that they've seen it work in mice and primates (rather than just petri dishes of human cells). I hope this goes well.
Hi! I'm a microbiologist and I've done work in academia, pharma, and clinical trials.
So the most exciting thing about this article is the last paragraph tbh (working on getting the actual paper, it's not up on sci-hub yet).
The company mentioned, Anokion, has four registered clinical trials for both Celiac and MS patients. The trial for Celiac just submitted data from their phase 1 trial (meaning there's good data it is safe) and are recruiting for a Phase 1/2 trial (meaning they are now testing efficacy). After that, the big hurdle is phase 3, which looks at whether or not it is better than a current treatment. The projected completion date is spring 2025. They are also preparing for a Phase 2 trial but are not yet recruiting.
The phase 1 MS trial is currently active, estimated completion in summer 2024.
I checked the company website and it looks like they are in the process of submitting an investigational new drug (IND) application for Type 1 diabetes. This is the first step to starting clinical safety and efficacy trials.
Now clinical trials can get delayed for a variety of reasons, but this is a really good sign! It's way further along than I initially thought when seeing the news. If the treatment does well, we could see new drugs on the market for Celiacs as early at 2030ish and MS as early as 2035.
I literally just burst into tears and woke up my partners.
Holy shit. The idea of not having celiac disease anymore is so completely overwhelming.
Update: I have registered for the trial and if you also have celiac and want to register the link is here.
