losing my mind at this amazing story from r/dndmemes some people’s dnd adventures are just. So Fucking Cool
They have accepted their fates
The Creeping Terror (1964) [colorized]
so my roommate is completely straight edge like no drugs no alcohol etc and so im sure y’all can imagine my surprise when i saw she brought home this sign
so i immediately inquired
and now you may ask. what the fuck did my roommate think that sign meant? well
anyways i moved the sign so it’s now front and center in our living room and ive been laughing every time i pass it
what a terrible time for me to remember that my roommate has a tumblr account and could theoretically find this post. *********** if you see this im sorry but it was funny and needed to be shared
I mean, botanically, “sativa” just means “cultivated” and “indica” means “of India”.
Cultivate to change the things I can run off to India
to accept the things I can't
Have fun in the war dumbass I’ll be at home fucking military wives
Damn. Good way to get your fucking windows kicked in
shut the fuck up and raise my son bootlicker
All fun and games until someone with 3 confirmed kills shows up at your doorstep with a baseball bat
im not at my house tho, im at yours with your wife
But he’s got shooters all over the world 🌎 even when he’s away
just shot a load in his wife
You ungrateful asshole. My bf might be fighting for your freedom and you’re here mocking him for keeping your pathetic ass safe from the threats of the world. If a war comes to our country, we’re not saving you, you dumbass ungrateful fuck up of a human being.
Your bf is fighting for oil and killing civilians and probably cheating on you he’s a scumbag, which is why I just fucked his mom to make a better son
The fool taunts the hungry dogs but the dogs have their day and the fool becomes a feast
your girl boutta be the feast soon as you get deployed boot boy
World Heritage Post
Who ever was the first person to post this is the biggest piece of shit in the world. You’re an amoral ASSHOLE!!!!!
Hotmeat89 you are a disgrace you don’t deserve to be called an American! You don’t even have the right to call yourself a MAN!
I don’t call myself a man but your wife still calls me to fuck
happy veterans day
what if I was sleepy and you also were sleepy and there were blankets and pillows. what then?
ALT
Voting as Fire Extinguishter (poem by Kyle Tran Myhre)
When the haunted house catches fire:
a moment of indecision.
The house was, after all, built on bones,
and blood, and bad intentions.
Everyone who enters the house feels
that overwhelming dread, the evil
that perhaps only fire can purge.
It’s tempting to just let it burn.
And then I remember:
there are children inside.
I’m sorry, I can’t come into work today. I didn’t get a long rest and god gave me a point of exhaustion. All my skill checks are at disadvantage.
Pubic hair more like public hair #show bush
This sounds political. Is this political
Yes my politics is bodily freedom
this joke was referencing George bush because im wasted off bottle of whiskey but I’m all for it
Who is George Bush
the only reason why ten year old girls are destroying stupidly overpriced products at sephora to make “skincare smoothies” is because they aren’t being given access to a yard with a variety of mud, sticks, rocks, puddles, and old ceramic planters to make potions in. the children yearn for the apothecary
wordle and bts may seem like they have nothing in common but both have been cited by redditors as the reason why their elderly relative quit watching fox news and started acting normal again
love wins i think
you can hate wordle or bts as much as you like, but in the time honored words of a long gone tumblr user: "shit dude whatever works I guess"
i cant help but notice that the chocolate chips cookies you brought to the potluck yesterday had bad vibes. so i went through your cabinets while you were sleeping and checked out the chocolate chips you used. i mean they looked innocent on the surface, they were even fair trade certified. but i just couldn't shake that itching sense that sometning was off. i infiltrated the chocolate company's headquarters by posing as IT support. and you know what I found? the guy who designed the labels got a dui in 2007. so it turns out my instincts were right and you're a terrible person.
“As a biologist, the terms biological woman and man don’t make any sense to me” okay then you’re an idiot and a terrible biologist. I swear to god, morons like you only become biologists just so you can hold it over others, when in reality, if biology deniers like you can become biologists, then being one really doesn’t mean much anyway. But this probably just gave an autogynophile like you a boner to read, anyway.
Oh fun! Haven't gotten one of these in a while. Disregarding the fact that you somehow think the qualification for being a biologist entirely hinges on defining womanhood, I do need to ask some clarification. I know I'm feeding the trolls here, but here we go: does your definition of "biological woman" mean:
Sociological woman? Eh, context dependent, I'm not fully out of the closet, but oftentimes, I am and present femme. So let's call that one 50/50.
Psychological woman? Because I am one.
Neurological woman? Because I am one [1].
Physical woman? My soft tissue redistribution is handling that well.
Hormonal woman? My blood tests are within cis female ranges.
Transcriptional woman? As a signalling molecule, the downstream effects of estrogen have broad transcriptional effects, completely changing the profile of gene expression and functional genomics of my cells. [2]
Genetic woman? I mean, see my above point- as far as my genes that are actually active, I have all of the same transcripts being produced, controlling which genes are expressed.
Karyotypic woman? I actually have a few signs pre-HRT that might point to a non-XY chromosome pair, but I haven't had a karyotype. We'll put that down as unknown. And hell, even if its XY, there's plenty of cis women who are karyotypically XY, with suppressed sry or complete androgen insensitivity. Interestingly enough, a completely androgen insesitive woman can go her whole life without knowing- and functionally, is very similar to a trans woman, actually. Fancy that. [3]
Reproductive woman? I can't produce an egg cell, but neither can significant fractions of cis women. Also, this is all gonna change soon, which is fun. [4]
There's also a lot of understudied aspects to the biology of HRT and even pre-HRT that are emerging, largely demonstrating widespread cellular and genetic remodeling of trans individuals undergoing hormone therapy. The field is a bit behind due to constant political pressure to revoke funding, but a lot of the results are extremely exciting in both testosterone and estrogen hormone therapies. I'm sure that, as a self professed biology As someone who presumably has a lot of expertise in biology, I'm assuming that you're aware of all of this cutting edge research, and are keeping up with modern papers, including but not limited to these cool findings:
- Trans men on HRT exhibit significant genetic and transcriptional changes that make them biochemically male. [5][6]. It's a good hypothesis that the same happens with estrogen treatment, but those studies don't exist yet- I'm sure you're reserving judgment until more publications exist, of course.
- Trans men on HRT develop male cell types and tissues. [7]
- Trans women experience muscular and blood cell changes that align with cis women moreso than cis men [8]
- And many, many more! This is an exciting, underserved, and groundbreaking field of research, and I'm sure you're keeping up with the latest in scientific journals about it.
I'm sure, of course, that you understand that it becomes impossible to draw a distinct line anywhere in here, and that words like "woman" are shorthand for the myriad of traits that invisibly synthesize in our mind and in society to represent a concept? I'm sure you understand that science is fundamentally descriptive, not prescriptive? I'm sure that you understand that these findings, while really cool and interesting, actually don't mean jack shit about what the word "woman" means or not?
As someone who is the ultimate decider in what a biologist is, I'm sure you know that bioessentiallism is a childish mindset that completely ignores and disregards the constantly changing, dynamic nature of biological systems, something that extends well beyond biological sex and its relation to gender.
I'm sure that also, that you understand that beyond just this, that the role of science in society is to advise how to achieve our moral principles, not create moral principles in themselves. And I'm sure that understanding means you know that trans affirming healthcare and supportive societal treatment leads to reduced mortality and increased happiness for everyone, right?
So great to talk to someone who is surely a scientist on this. You are a biologist, if you're talking like this, I assume? I assume you're not going to spit complete misreadings of scientific language from the background sections of these papers that only reveal you've never read a scientific paper in your life if you're thinking this way? I assume you have experience interpreting data like this?
Also, imagining my genitalia while writing this? Ew. Please stop projecting your fetishes into my inbox.
Works cited:
- Kurth F, Gaser C, Sánchez FJ, Luders E. Brain Sex in Transgender Women Is Shifted towards Gender Identity. J Clin Med. 2022 Mar 13;11(6):1582. doi: 10.3390/jcm11061582. PMID: 35329908; PMCID: PMC8955456.
- Fuentes N, Silveyra P. Estrogen receptor signaling mechanisms. Adv Protein Chem Struct Biol. 2019;116:135-170. doi: 10.1016/bs.apcsb.2019.01.001. Epub 2019 Feb 4. PMID: 31036290; PMCID: PMC6533072.
- Gottlieb B, Trifiro MA. Androgen Insensitivity Syndrome. 1999 Mar 24 [Updated 2017 May 11]. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1429/
- Murakami, K., Hamazaki, N., Hamada, N. et al. Generation of functional oocytes from male mice in vitro. Nature 615, 900–906 (2023). https://doi.org/10.1038/s41586-023-05834-x
- Pallotti F, Senofonte G, Konstantinidou F, Di Chiano S, Faja F, Rizzo F, Cargnelutti F, Krausz C, Paoli D, Lenzi A, Stuppia L, Gatta V, Lombardo F. Epigenetic Effects of Gender-Affirming Hormone Treatment: A Pilot Study of the ESR2 Promoter's Methylation in AFAB People. Biomedicines. 2022 Feb 16;10(2):459. doi: 10.3390/biomedicines10020459. PMID: 35203670; PMCID: PMC8962414.
- Florian Raths, Mehran Karimzadeh, Nathan Ing, Andrew Martinez, Yoona Yang, Ying Qu, Tian-Yu Lee, Brianna Mulligan, Suzanne Devkota, Wayne T. Tilley, Theresa E. Hickey, Bo Wang, Armando E. Giuliano, Shikha Bose, Hani Goodarzi, Edward C. Ray, Xiaojiang Cui, Simon R.V. Knott, The molecular consequences of androgen activity in the human breast, Cell Genomics, Volume 3, Issue 3, 2023, 100272, ISSN 2666-979X, https://doi.org/10.1016/j.xgen.2023.100272. (https://www.sciencedirect.com/science/article/pii/S2666979X23000320)
- Xu R, Diamond DA, Borer JG, Estrada C, Yu R, Anderson WJ, Vargas SO. Prostatic metaplasia of the vagina in transmasculine individuals. World J Urol. 2022 Mar;40(3):849-855. doi: 10.1007/s00345-021-03907-y. Epub 2022 Jan 16. PMID: 35034167.
- Harper J, O'Donnell E, Sorouri Khorashad B, McDermott H, Witcomb GL. How does hormone transition in transgender women change body composition, muscle strength and haemoglobin? Systematic review with a focus on the implications for sport participation. Br J Sports Med. 2021 Aug;55(15):865-872. doi: 10.1136/bjsports-2020-103106. Epub 2021 Mar 1. PMID: 33648944; PMCID: PMC8311086.
I love to hit bioessentialist bigots with essays that they won't read. Even so, the essays will erode their support for their fascist attempts at societal and cultural regression. And writing essays dunking on bioessentialists is really hot :3
literally my favorite type of tweet
oh my god i have some of these saved 1 sec
every day I think about the religious anime girls…
And how the artist drew several pro-Palestine drawings like this one
in 2014, that’s right, 2014, this did not fucking start October 7th.