Oh definitely, I feel like "blames himself for what happened" is a classic Peter trait across any universe that's worth keeping tracking of. The fact that he couldn't have known that his actions would inadvertently lead to her being attacked doesn't mean that he isn't going to feel that he's responsible for having put her in that danger and failed to protect her. It's consistent with his core characteristics and it's an element of the dynamic between Felicia and Peter post-Eyes Without A Face that I'm particularly interested in exploring in my artwork of them.
More broadly on the topic of blaming himself, we see interesting differences in where his sense of guilt originates and how it plays out in Noir compared to 616. After all, in Noir his uncle is killed prior to the main plot under circumstances that were absolutely not related to Peter's actions, and so a lifelong sense of guilt isn't part of his reaction to that specific event like it is in 616 (I would say that Felicia and Robbie's injuries in Eyes Without a Face fill this role instead). Noir's version of the classic "with great power comes great responsibility" line therefore isn't a lesson learned from how Peter's failure to act led to his uncle's death; in this universe, the line goes "if those in power can't be trusted, it's the responsibility of the people to remove them" and it's something that he was told by his uncle that's specifically linked to communist/socialist organizing and the violence of the first world war. Pretty different! And those differences manifest in interesting ways regarding Noir!Peter's methods and motivations, which is a big part of why I like this particular universe so much.