an all-stress hot mess doing my best

I am HOWLING!

One coathanger: *snaps instantly*

This abolute treasure of a man: How about TWO coathangers?

you've gotta have friends who are older than you, not because you're a dumb kid, but because you'll be terrified of growing up otherwise

being the oldest person you allow yourself to know will eat holes in your brain and you'll start saying weird stuff

Get a hobby that is intergenerational.  The friendships with people much older and much younger than you will mean that wisdom and ideas are shared among many and not isolated among the few.  

People feel like they have to... Justify their ships now? When the hell did that start? Ask me why I ship something and it's like, the characters were in a room together one time. The fuck more do you expect from me?

sometimes they werent even in the same room but like what if they were

I put them in a room together in my mind and they were quite cute

Ok but like. What the fuck is there to do on the internet anymore?

Idk when I was younger, you could just go and go and find exciting new websites full of whatever cool things you wanted to explore. An overabundance of ways to occupy your time online.

Now, it’s just… Social media. That’s it. Social media and news sites. And I’m tired of social media and I’m tired of the news.

Am I just like completely inept at finding new things or has the internet just fallen apart that much with the problems of SEO and web 3.0 turning everything into a same-site prison?

Long collection of resources under the cut.

Keep reading

ALSO you should consider browsing Virtual Pet List and seeing if there are any pet sites you might be interested in playing. There is a whole genre of browser games right under your nose

Another one that I just found recently is this, which is a whole collection of blogs, organized by topic!

Look guys the real internet IS STILL THERE I’m going to cry

Getting off of twitter and onto neocities has really healed me and I am so glad to see it is healing other people too ;u; let’s retreat into the self-made digital woods and away from corporate bs pls, I am so tired

I kinda lived half of 2023 (maybe more) like a drowning rat in a bucket but this year I'll live like a normal rat. outside of a bucket

This was shared as a "bad" joke but I was so charmed by it I've been thinking about it for days.

(after misunderstanding what someone said and embarrassing myself) oh great now they hate me and want to kill me with rocks

Is this a prank? What….

Edit: holy heck it’s real…

They might be able to help us…

The stage that they're at is animal testing but it sounds like it's been successful in mouse and primate models.

My understanding: The way autoimmune diseases usually seem to work* is the immune system is "flagging" the wrong thing as harmful/not needed and destroying it. The typical treatments for autoimmune diseases are just tamping the entire immune system down so it can't destroy anything, which leaves a person vulnerable to infection.

The newer method is basically "tricking" the body using a method that... the human body already came up with. Cells flagging the wrong thing apparently happens all the time, so there are multiple defenses against immune disease, and one of them is in the liver. So scientists figured out a way to tell the body "hey, you flagged this wrong" and sent it to the liver and the liver/body recognized this signal.

There is still a lot of work to be done and it sounds like this isn't foolproof (ie: what if the liver is whats broken? unsure, and what if the immune system flags things wrong again?) but this is literally so amazing. i was tearing up reading it, and i hope that everything goes well in clinical trials.

*theres like a lot medical science doesnt know about the immune system

Thank you for this explanation/synthesis of the article! It's important for us to understand that they're still in early development and testing of these methods, but also that they've seen it work in mice and primates (rather than just petri dishes of human cells). I hope this goes well.

Hi! I'm a microbiologist and I've done work in academia, pharma, and clinical trials.

So the most exciting thing about this article is the last paragraph tbh (working on getting the actual paper, it's not up on sci-hub yet).

The company mentioned, Anokion, has four registered clinical trials for both Celiac and MS patients. The trial for Celiac just submitted data from their phase 1 trial (meaning there's good data it is safe) and are recruiting for a Phase 1/2 trial (meaning they are now testing efficacy). After that, the big hurdle is phase 3, which looks at whether or not it is better than a current treatment. The projected completion date is spring 2025. They are also preparing for a Phase 2 trial but are not yet recruiting.

The phase 1 MS trial is currently active, estimated completion in summer 2024.

I checked the company website and it looks like they are in the process of submitting an investigational new drug (IND) application for Type 1 diabetes. This is the first step to starting clinical safety and efficacy trials.

Now clinical trials can get delayed for a variety of reasons, but this is a really good sign! It's way further along than I initially thought when seeing the news. If the treatment does well, we could see new drugs on the market for Celiacs as early at 2030ish and MS as early as 2035.

I literally just burst into tears and woke up my partners.

Holy shit. The idea of not having celiac disease anymore is so completely overwhelming.

Update: I have registered for the trial and if you also have celiac and want to register the link is here.

When public services are affordable and convenient, people will always choose those resources. They are not supposed to be a capitalistic profit-seeking initiative, they are developed for the benefit of the people, for a better life, just as government resources should be used. (tweet)

Update from Boston, where they have removed fares from 3 bus lines and ridership is up 48% in low-income areas.

Yeah it fuckin is

Want more go to a meeting about it

John Astin and Carolyn Jones - The Addams Family (1964)

careless whisper fucks so insanely hard and i will never forgive the internet for making it a "meme song." tonight the music seems so loud i wish that we could lose this crowd maybe its better this way we'd hurt each other with the things we want to say. if you even care.

I told all the crows about what you did btw. Good luck next time you’re in the forrest

one of the best academic paper titles

for those who don't speak academia: "according to our MRI machine, dead fish can recognise human emotions. this suggests we probably should look at the results of our MRI machine a bit more carefully"

I hope everyone realises how incredibly important this dead fish study is. This was SO fucking important.

I still don’t understand

So basically, in the psych and social science fields, researchers would (I don't know if they still do this, I've been out of science for awhile) sling around MRIs like microbiolosts sling around metagenomic analyses. MRIs can measure a lot but people would use them to measure 'activity' in the brain which is like... it's basically the machine doing a fuckload of statistics on brain images of your blood vessels while you do or think about stuff. So you throw a dude in the machine and take a scan, then give him a piece of chocolate cake and throw him back in and the pleasure centres light up. Bam! Eating chocolate makes you happy, proven with MRI! Simple!

These tests get used for all kinds of stuff, and they get used by a lot of people who don't actually know what they're doing, how to interpret the data, or whether there's any real link between what they're measuring and what they're claiming. It's why you see shit going around like "men think of women as objects because when they look at a woman, the same part of their brain is active as when they look at a tool!" and "if you play Mozart for your baby for twenty minutes then their imagination improves, we imaged the brain to prove it!" and "we found where God is in the brain! Christians have more brain activity in this region than atheists!"

There are numerous problems with this kind of science, but the most pressing issue is the validity of the scans themselves. As I said, there's a fair bit of stats to turn an MRI image into 'brain activity', and then you do even more stats on that to get your results. Bennett et. al.'s work ran one of these sorts of experiments, with one difference -- they used a dead salmon instead of living human subjects. And they got positive results. The same sort of experiment, the same methodology, the same results that people were bandying about as positive results. According to the methodology in common use, dead salmon can distinguish human facial expressions. Meaning one of two things:

I cannot overstate just how many papers were completely fucking destroyed by this experiment. Entire careers of particularly lazy scientists were built on these sorts of experiments. A decent chunk of modern experimental neuropsychology was resting on it. Which shows that science is like everything else -- the best advances are motivated by spite.

As someone who took etiquette lessons, politeness is an incredibly effective tool for disarming bigots. You can either force them to reconsider their words/actions by directly and calmly confronting their behavior (by using the rules of society in your favor), or you can dip entirely while they appear to be in the wrong.

Both options are great.

Because the thing is, when bigots pick fights, they are 100% counting on you to get louder than them. Or meaner. They want you to react emotionally and provide fodder for their 'You're Too Emotionally Immature To Understand' cannon.

What they aren't expecting you to do is say one of the following phrases in a polite, concerned tone:

For those of you who'd are spiteful and/or dealing with Fundamentalists/Evangelicals/generally shitty Christians:

And my all time favorite:

"It sounds to me like there are some seriously dark and angry forces at work in your heart."

(Nothing stops a Christian bigot in their tracks faster than implying the Devil is causing their bigotry. But you MUST be calm, polite, and gentle with your tone and wording. It is absolutely fair to twist the rules and play them at their own game, but you gotta play hard.)

TLDR: It's much faster to use etiquette, politeness, and rhetoric reversal when eviscerating idiots online and in person, because they aren't expecting you to weaponize their behaviors back in their direction. Don't get angry, get spitefully polite! :)